Caelestines A-D, brominated quinolinecarboxylic acids from the Australian ascidian Aplidium caelestis.
نویسندگان
چکیده
Four new brominated natural products, caelestines A-D (1-4), have been isolated from the Australian ascidian Aplidium caelestis. The structures of 1-4 were determined by analysis of their NMR and MS data. This is the first report of brominated quinolinecarboxylic acids from nature. Compound 1 has been previously synthesized but not spectroscopically characterized. Compounds 1-4 were tested against three mammalian cell lines (MCF-7, NFF, and MM96L) and a panel of microbial strains and showed only minor cytotoxicity.
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عنوان ژورنال:
- Journal of natural products
دوره 73 9 شماره
صفحات -
تاریخ انتشار 2010